Sincere apologies - I must be missing something because there are a lot of posts on the topic of flow control.

The datasheet states "Control signals supported by UART mode include RTS, CTS. .... RTS/CTS and XON/ XOFFhandshaking options are also supported"

Where are these options selected?  I have gone through FT_Prog and can find nothing other than signal inversion settings.  The D2XX_Programmer's_Guide provides options to set flow control, but that would require a D2XX based program to configure them (or is that somehow managed by the VCP enumeration??)  If so then what is the power up condition of the chip - ie is there any handshaking prior to configuration? 

Thanks in advance,
Colin